合成生物制造2026

Biomanufacturing driven by engineered organisms (2026)

摘要:

2025年，合成生物学与生物制造领域呈现出“智能融合、系统优化、应用多元”的鲜明特征。人工智能已从辅助工具演变为核心驱动力，深度融入从生物元件设计到发酵过程控制的全链条，推动研发范式从“经验驱动”向“数据与模型驱动”的根本性转变。酶工程与蛋白质设计的突破不断拓展生物催化的功能边界，细胞工厂的构建正从单靶点改造迈向全局系统优化，传统底盘与新型底盘协同发展，推动高值化学品与新质蛋白的高效生物合成。环境生物修复从功能菌株改造走向人工合成微生物组的理性设计，标志着生物修复迈向可预测、可调控的新阶段。与此同时，人工细胞等前沿交叉领域的突破持续拓展着生物制造的边界与想象空间。展望未来，人工智能与自动化平台的深度集成、对生命系统复杂性的深入解析以及面向碳中和目标与人民健康需求的产业应用，将是领域发展的核心方向。合成生物制造正从“造物致知、造物致用”走向“造物致善、造物致远”，为人类社会应对资源、环境与健康等世纪挑战贡献不可替代的解决方案。

Abstract:

In 2025, synthetic biology and biomanufacturing have demonstrated remarkable progress characterized by intelligent integration, systematic optimization, and diversified applications. Artificial intelligence has evolved from an auxiliary tool into a core driving force, deeply embedded throughout the entire pipeline from biomolecular design to fermentation process control, catalyzing a fundamental shift from “experience-driven” to “data- and model-driven” research paradigms. Breakthroughs in enzyme engineering and protein design continue to expand the functional boundaries of biocatalysis, while cell factory construction is advancing from single-target modification toward global systematic optimization. The synergistic development of traditional and emerging chassis hosts enables efficient biosynthesis of high-value chemicals and novel proteins. Environmental bioremediation is transitioning from functional strain engineering to the rational design of synthetic microbial consortia, marking a new era of predictable and controllable remediation strategies. Meanwhile, advances in interdisciplinary frontiers, such as artificial cells, are continuously expanding the horizons of biomanufacturing. Looking forward, the deep integration of artificial intelligence with automation platforms, a deeper understanding of biological complexity, and industrial applications aligned with carbon neutrality goals and human health demands will define the future trajectory of the field. Synthetic biomanufacturing is evolving from “understanding life by creating life and creating life for applications” toward “creating life for good and creating life for the future”, offering indispensable solutions to address global challenges in resources, environment, and health.