抗猪流行性腹泻病毒活性物质及其作用机制研究进展

Research progress in active substances and their mechanisms of action against porcine epidemic diarrhea virus

摘要:

猪流行性腹泻病毒(porcine epidemic diarrhea virus,PEDV)是一种能引起猪流行性腹泻的肠道冠状病毒，可致仔猪腹泻、呕吐、消瘦甚至死亡。由于PEDV毒株类型多样，传统疫苗难以持续有效防治。本文综述了活性物质调控胞内信号通路及病毒蛋白、微生物代谢产物提高宿主免疫机能等抗PEDV策略及其作用机理，并强调了PEDV耐药性产生和PEDV突破种间屏障可能带来的危害，为新型抗病毒药物或疫苗研制提供了参考。

Abstract:

Porcine epidemic diarrhea virus (PEDV) is an intestinal coronavirus that can cause porcine epidemic diarrhea, leading to diarrhea, vomiting, weight loss, and even death in piglets. Due to the diversity of PEDV strains, traditional vaccines are difficult to sustainably and effectively prevent and control PEDV. This article reviews the strategies and mechanisms of active substances in regulating intracellular signaling pathways, viral proteins, and microbial metabolites to enhance the host immune function against PEDV. It emphasizes the prevention of PEDV resistance and the potential harm of PEDV breaking through interspecies barriers to the human society, aiming to provide reliable theoretical support for the development of new antiviral drugs or vaccines.