芽孢杆菌抗菌物质研究进展

Advances in the antimicrobial substances in Bacillus

摘要:

芽孢杆菌是一类能够产生芽孢的革兰氏阳性细菌，能够产生多种结构和功能各异的抗菌物质。通过应用芽孢杆菌所产生的抗菌活性物质，能够有效抑制有害细菌和真菌的活性，促进绿色农业可持续发展。芽孢杆菌产生的抗菌物质主要包括蛋白质、脂肽、聚酮和多肽等，本文对芽孢杆菌产生的各类抗菌物质的合成基因簇、合成途径、结构与作用机制等进行综述，同时深入探讨了芽孢杆菌抗菌物质产业化应用面临的挑战，明确了未来的研发重点，并对其应用前景进行了展望，为芽孢杆菌抗菌物质的深入研究和广泛应用提供了更全面的理论支持。

Abstract:

Bacillus is a class of spore-producing Gram-positive bacteria that produce a variety of antimicrobial substances with different structures and functions. The application of the antimicrobial substances produced by Bacillus can effectively inhibit the activity of harmful bacteria and fungi and promote the sustainable development of green agriculture. The antimicrobial substances produced by Bacillus mainly include proteins, lipopeptides, polyketones, and polypeptides. This paper reviews the synthesis gene clusters, synthesis pathways, structures, and mechanisms of various antimicrobial substances produced by Bacillus and discusses the challenges in the industrial application of these antimicrobial substances. Furthermore, this paper clarifies the future research and development focuses and prospects the application prospects, and provides comprehensive theoretical support for the in-depth research and wide application of the antimicrobial substances produced by Bacillus.