长链非编码RNA与糖尿病及其并发症

Role of long non-coding RNA in diabetes mellitus and its complications

摘要:

长链非编码RNA起初被认定是基因转录“噪音”，随着DNA元件百科全书的研究进展发现，lncRNA能以RNA的形式在表观遗传、转录以及转录后水平调控基因的表达，参与多种重要的生命调控过程，与人类疾病的发生发展和预防都有着紧密联系。文章介绍lncRNA的功能和特点，结合对lncRNA的研究思路，并在已有研究的基础上综述lncRNA与糖尿病及其并发症的关系，这些研究进展将为进一步理解糖尿病及其发生发展的分子医学基础提供依据。

Abstract:

Long non-coding RNA was initially identified as “noises” of gene transcriptions. However, with the developing researches of ENCODE, it was found that the long non-coding RNAs can regulate the genomic expressions in the form of RNAs in epigenetic, transcription, and post transcriptional levels, which is involved in the regulation of diverse cellular processes and has significant influences on occurrence and precaution of human diseases. This paper introduces functions and features of the long non-coding RNAs, and sums up the internal relation between long non-coding RNAs, diabetes and diabetic complications on the basis of existing researches. These advances can provide the basis for the further understanding of molecular medicine on occurrence and evolution of diabetes.