Manipulation of NADH metabolism in industrial strains

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Manipulation of NADH metabolism in industrial strains
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Fund Project:the National Outstanding Youth Foundation of China (No. 20625619); the National Natural Science Foundation of China (Nos. 30670066, 20706025), the National High-tech Research Development Plan of China (863 Program) (No. 2006AA02Z201), and the Major State Basic Research Development Program of China (973 Program) (No. 2007CB714303).

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Abstract:

Nicotinamide adenine nucleotide (NADH), the key cofactor in the metabolic network, plays an essential role in biochemical reaction and physiological function of industrial strains. Manipulation of NADH availability and form is an efficient and easy way to redirect the carbon flux to the target metabolites in industrial strains. We reviewed the physiological function of NADH. Detailed strategies to manipulate NADH availability are addressed. NADH manipulation to enhance metabolic function of industrial strains was discussed and potential solutions were suggested.

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秦义,董志姚,刘立明,陈坚. 工业微生物中NADH的代谢调控[J]. Chinese Journal of Biotechnology, 2009, 25(2): 0161-0169

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Received:August 04,2008
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