Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone

Abstract:

1,3-Dihydroxyacetone is widely used in cosmetics, medicines and food products. We reviewed the recent progress in metabolic pathways, key enzymes, as well as metabolic engineering for microbial production of 1,3-dihydroxyacetone. We addressed the research trend to increase yield of 1,3-dihydroxyacetone by improving the activity of glycerol dehydrogenase with genetic engineering, and regulating of fermentation process based on metabolic characteristic of the strain.

Key words:1,3-dihydroxyacetone, metabolic engineering, fermentation, glycerol