Progress in co-culture and differentiation in adipose-derived stem cells: a review

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Progress in co-culture and differentiation in adipose-derived stem cells: a review
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Fund Project:Key Projects in the National Science and Technology Pillar Program during the Eleventh Five-Year Plan Period (No. 2006 BAIⅡ B08-03), E-Institutes for Nitric Oxide and Inflammatory Medicine (No. E-04010), Project of Modernization of Traditional Chinese Medicine, Shanghai Committee of Science & Technology (No. 08DZ1972104), National Science and Technology Major Project of the Ministry of Science and Technology of China (No. 2009ZX09311-003).

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Abstract:

Stem cells can be differentiated into many kinds of somatic cells under defined culture conditions. In addition, the homing possess can be partially imitated by co-culture of stem cells with mature somatic cells. Regarding the importance of clinical application of adipose-derived stem cells (ADSCs), our review first introduced the sources and signs of ADSCs, and then the current knowledge of ADSCs co-culture technology, including drug and chemical induced culture, two-dimensional (2D) and three-dimensional (3D) co-culture, mechanisms of ADSCs differentiation, and application development in recent years in details. Finally, we also addressed prospects of ADSCs.

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聂绪强,陈怀红,唐宁,卞卡. 脂肪干细胞的共培养及其分化应用概述[J]. Chinese Journal of Biotechnology, 2011, 27(8): 1121-1131

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Received:December 07,2010
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