Paclitaxel induced apoptotic genes and pathways alterations: a review
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National Natural Science Foundation of China (No. 30970090), Ministry of Education Program for New Century Excellent Talents, Chinese Postdoctoral Science Foundation (No. 20090450136), Science and Technology Innovation Talent Research Special Funds of Harbin (No. 2010RFQXS043), New Century Excellent Talents of Heilongjiang Provincial University (No. 1251-NCET-005), the Education Department of Heilongjiang Province Science and Technology Research Projects (No. 11551377).

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    Abstract:

    Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis.

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刘丹,康宏,孙传真,肖野,赵凯. 紫杉醇诱导凋亡的信号传导通路及与凋亡相关的基因和蛋白[J]. Chinese Journal of Biotechnology, 2013, 29(2): 153-160

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  • Received:October 10,2012
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  • Online: March 08,2013
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