Anti-biofilm effects of Zn lactate·3H2O and SnF2 on Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus mutans

Abstract:

Zn lactate and SnF2 were used as active compounds in the dentifrice. Here, their anti-biofilm effects were evaluated on Pseudomonas aeruginosa, Acinetobacter baumannii and Streptococcus mutans. The biofilm prevention/ dispersal assay of P. aeruginosa PAO1 demonstrated that Zn lactate and SnF2 can inhibit biofilm formation independently or by combined treatment. Zn lactate disrupted extracellular polysaccharides matrix formation and SnF2 reduced the biomass of biofilm. Most importantly, the combination of Zn lactate and SnF2 thoroughly abolished the biofilm formation of all three strains.

Key words:Pseudomonas aeruginosa, Zn lactate·3H2O, SnF2, biofilm, Acinetobacter baumannii, Streptococcus mutans