Catalysis of enzymes under industrial environment and their adaptive modifications: a review
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National Key Research and Development Project (No. 2017YFE0129400), Natural Science Foundation of Zhejiang Province (No. LR19B06001).

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    Abstract:

    Enzymes have a wide range of applications and great industrial potential. However, large-scale applications of enzymes are restricted by the harsh industrial environment, such as high temperature, strong acid/alkali, high salt, organic solvents, and high substrate concentration. Adaptive modification (such as rational or semi-rational design, directed evolution and immobilization) is the most common strategy to improve the catalysis of enzymes under industrial conditions. Here, we review the catalysis of enzymes in the industrial environment and various methods adopted for the adaptive modifications in recent years, to provide reference for the adaptive modifications of enzymes.

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王文豪,闻鹏飞,许孔亮,郑仁朝,郑裕国. 工业环境下酶蛋白的催化行为与适应性改造研究进展[J]. Chinese Journal of Biotechnology, 2019, 35(10): 1857-1869

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  • Received:June 16,2019
  • Online: October 24,2019
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