Intrinsically disordered proteins (IDPs) and the impact on cell stress resistance

Abstract:

Intrinsically disordered proteins (IDPs) are proteins or protein regions that fail to get folded into definite three-dimensional structures but participate in various biological processes and perform specific functions.Defying the traditional protein "sequence-structure-function" paradigm,they enrich the protein "structure-function" diversity.Ubiquitous in organisms,they show extreme hydrophilicity,charged amino acids,and highly repetitive amino acid sequences,with simple arrangement.As a result,they feature highly variable binding affinities and high coordination,which facilitate their functions.IDPs play an important role in cell stress response,which can improve the tolerance to a variety of stresses,such as freezing,high salt,heat shock,and desiccation.In this study,we briefed the characteristics,classifications,and identification of IDPs,summarized the molecular mechanism in improving cell stress resistance,and described the potential applications.