Zn2+依赖型组蛋白去乙酰化酶在植物非生物胁迫响应中的作用及机制

Functions and mechanisms of Zn2+-dependent histone deacetylase in plant responses to abiotic stress

摘要:

Zn²⁺依赖型组蛋白去乙酰化酶(Zn²⁺-dependent histone deacetylases,HDAs)是一类与酵母还原性钾依赖型3(reduced potassium dependency 3,RPD3)高度同源的去乙酰化酶蛋白家族。HDAs通过去除组蛋白和非组蛋白赖氨酸残基上的乙酰基而广泛调控染色体稳定、基因转录和蛋白质活性。在植物中，HDAs介导的去乙酰化修饰在植物生长发育和非生物胁迫响应中发挥重要作用。本文综述了植物HDAs的发现、结构与分类、去乙酰化机制，重点总结了该蛋白家族在植物非生物胁迫中的调控作用，并对未来研究方向进行展望，为HDAs介导的表观遗传学研究提供了理论支持。

关键词:Zn²⁺依赖型组蛋白去乙酰化酶;表观遗传;去乙酰化;非生物胁迫

Abstract:

The HDAs (a subfamily of histone deacetylases), a class of Zn²⁺-dependent histone deacetylases, are highly homologous to the reduced potassium dependency 3 (RPD3) in yeast. HDAs extensively regulate chromosome stability, gene transcription, and protein activity by catalyzing the removal of acetyl group from histone and non-histone lysine residues. HDA-mediated deacetylation is essential for plant growth, development, and responses to abiotic stress. We review the research progress in HDAs regarding the discovery, structures, classification, deacetylation process, and roles in regulating plant responses to abiotic stress. Furthermore, this paper prospects the future research on HDAs, aiming to provide theoretical support for the research on epigenetic regulation mediated by HDAs.

Key words:Zn²⁺-dependent histone deacetylases;epigenetics;deacetylation;abiotic stress