环糊精糖基转移酶产物专一性改造：难题与挑战

The Product Specificity Evolution of Cyclodextrin Glucanotransferase: Problems and Challenges

摘要:

生产环糊精所必需的环糊精糖基转移酶与其产物专一性进化研究已经成为当今的研究热点。这项研究中的进展不仅会使环糊精糖基转移酶的应用取得突破结果，还会对其它酶的改造提供帮助。目前，人们对这类酶的性质已经有了较为深入的认识，但还存在着一些尚未解决的问题，如酶产物专一性的决定因素尚未系统阐明等。通过对环糊精糖基转移酶各个方面，尤其是其产物专一性进化方面研究的回顾，指出并分析了研究中尚未解决的问题，并对将来这一研究领域的前景进行了展望。

Abstract:

Cyclodextrin glucanotransferase, the essential enzyme for the production of cyclodextrins, has become the focus of scientific research nowadays. Although many related enzyme properties are well known, the crucial factors in product specificity determination remain to be answered. Here, the recent research progresses of cyclodextrin glucanotransferase, especially those about the evolution of product specificity, were reviewed, and the scientific problems were discussed.