胶原蛋白结构基础上的设计与合成

Structure-based Design and Biosynthesis of Collagen Proteins

摘要:

胶原蛋白在人体组织中的含量十分丰富，它是具有绕轴周期性螺旋（即三重螺旋）结构的纤维状蛋白，它为细胞粘附和大分子的沉积等提供支架结构。随着基因工程技术和生物材料科学的不断发展，以及对如何获得具有特殊功能胶原蛋白研究的不断深入，使其成为第三代生物材料中倍受瞩目的成员之一。基于胶原蛋白结构的分子设计以及合成途径值得探讨。

Abstract:

Collagen is the most abundant protein in human body and a periodic helix, i.e., triple helix, fibrous protein, which provides the scaffold structures for the cell adhesion and macromolecule aggregation, etc. With the development of gene engineering and biomaterial technologies, and the incessant studies on the technique to obtain the proteins with special functions, the collagen protein has been one of the third generation biomaterials that attract more attention than others. In this paper, we reviewed the recent structure-based design and biosynthesis of collagen.