植物萜类代谢工程

Metabolic Engineering of Terpenoids in Plants

摘要:

植物萜类化合物不仅在植物生命活动中起重要作用，而且具有重要商业价值。随着近年来萜类代谢途径和调控机理研究的深入，代谢工程已成为提高萜类产量最有潜力的途径之一。对萜类代谢工程领域具代表性的研究结果进行了全面回顾，然后讨论了萜类代谢工程的研究方法和策略，其中重点探讨了功能基因组学方法在萜类代谢途径及调控机理研究方面的应用。

Abstract:

Terpenoids are present in all organisms but are especially abundant in plants，with more than 30 000 compounds. Not only do they play an important role in the life of plant，but also have high commercial values. However，the content of many important terpenoids in plant is very low. Therefore，how to improve the inefficient production of terpenoids is an urgent task. Metabolic engineering has been one of the most potential technologies to improve terpenoids production in recent years，following the study of metabolic pathway and regulation mechanism of terpenoids. Although there are some breakthroughs，metabolic engineering of terpenoids is still full of challenges because of the lack of knowledge on metabolic control of most terpenoids. Functional genomics approaches，including transcriptomics，proteomics and metabolomics，are potential tools for exploring of metabolic engineering. Integrating transcriptomics and metabolomics is an effective way to discover new genes involved in metabolic pathway. In this paper，the representative research outcomes about the metabolic engineering of terpenoids in plant were reviewed concisely and then the application of functional genomics approaches to study metabolic pathway and regulation mechanism of terpenoids and the strategies for metabolic engineering of terpenoids were discussed.