谷胱甘肽/谷胱甘肽过氧化物酶系统在微生物细胞抗氧胁迫系统中的作用

The Function of Glutathione/Glutathione Peroxidase System in the Oxidative Stress Resistance Systems of Microbial Cells

摘要:

谷胱甘肽(GSH)/谷胱甘肽过氧化物酶(GPx)系统在不同微生物细胞抵抗氧胁迫中的生理功能不尽相同。该系统在真核模式微生物酿酒酵母中是必需存在的，在维持胞内氧化还原平衡和抵抗氧胁迫中发挥主要作用。然而，在原核微生物中，该系统只是条件性的，即部分胞内存在谷胱甘肽还原酶和GPx的原核微生物，如流感嗜血杆菌和乳酸乳球菌，可通过从胞外吸收GSH，形成条件性的依赖于GSH的GPx系统，参与抵抗氧胁迫。

Abstract:

The physiological roles of the glutathione(GSH)/glutathione peroxidase(GPx) system in protecting microbial cells against oxidative stress were reviewed. In eukaryotic model microbeSaccharomyces cerevisiae，this system is obligatory in maintaining the redox balance and defending the oxidative stress. However，The GSH/GPx system only conditionally exists in prokaryotes. Namely，for those prokaryote bacteria containing glutathione reductase and GPx，e.g. Haemophilus influenzae and Lactococcus lactis，by taking up GSH，they might develop a conditional GSH-dependent GPx reduction system，which conferred cells a stronger resistance against oxidative challenge.