EGCG的生物学活性及其调节卵母细胞老化的研究进展

Research progress in biological activities and oocyte aging-regulating effect of EGCG

摘要:

表没食子儿茶素没食子酸酯(epigallocatechin gallate, EGCG)是绿茶中一类含量最高的次级代谢产物，具有抗氧化、抗癌和抗炎等多种生理活性。EGCG在调节卵母细胞老化的过程中起重要作用，主要通过增强卵母细胞的抗氧化能力、改善线粒体功能和减少细胞凋亡来延缓卵母细胞的衰老进程。本文对EGCG主要分子特性及其调节卵母细胞老化的作用机制进行综述，为深入理解EGCG在减缓卵母细胞老化中的作用提供了参考。

Abstract:

Epigallocatechin gallate (EGCG), the predominant polyphenol in green tea, exerts a spectrum of physiological activities, including antioxidant, anticancer, and anti-inflammatory effects. Emerging research underscores the significance of EGCG in modulating oocyte aging. EGCG can enhance antioxidant defenses, improve mitochondrial functions, and inhibit apoptotic pathways, thereby retarding the aging of oocytes. This review delineates the main molecular features of EGCG and expounds its regulatory mechanisms concerning oocyte aging, enriching the knowledge on the role of EGCG in the amelioration of oocyte aging.