蓝舌病病毒抗宿主干扰素免疫应答机制研究进展

Advances in the anti-host interferon immune response of bluetongue virus

摘要:

蓝舌病病毒(bluetongue virus, BTV)常通过媒介昆虫库蠓叮咬感染绵羊、牛、鹿等，引起家养及野生反刍动物蓝舌病(bluetongue, BT)。目前BT在全球亚热带甚至温带地区广泛分布，严重威胁世界畜牧业发展及国际贸易。本文介绍了BTV结构及其细胞侵入过程，并对宿主细胞抗BTV免疫应答以及BTV非结构蛋白NS3、NS4和结构蛋白VP3、VP4等拮抗宿主细胞天然免疫应答机制进行综述，为深入了解BTV拮抗宿主细胞干扰素(interferon, IFN)免疫应答的分子机制及研究BTV致病机制和新型疫苗提供了参考。

Abstract:

Bluetongue virus (BTV) usually infects sheep, cattle, deer and other domesticated and wild ruminants through the bite of the vector insects, Culicoide, causing bluetongue (BT). BT in subtropical and even temperate regions poses a serious threat to the development and international trade of the livestock industry. This article introduced the structure and cellular invasion, and summarized the mechanisms of anti-BTV immune response of host cells and antagonism of host cell innate immune response by the non-structural proteins (e.g., NS3 and NS4) and structural proteins (e.g., VP3 and VP4) of BTV. This review provided a basis for understanding the antagonism mechanisms of BTV against the interferon (IFN) immune response in the host cell and the pathogenesis of BTV as well as for developing novel vaccines against this virus.