基于壳聚糖的生物组装技术及应用研究进展

Biofabrication with chitosan and its application progress

摘要:

壳聚糖是一种具有良好生物相容性、独特pH值响应性、易改性和易成膜特性的高分子材料。在生物组装技术中, 壳聚糖可作为多功能活性介体, 与生物组分和微加工装置连接, 制成高选择性、高灵敏度的生物微机电系统(BioMEMS)。以下介绍了基于壳聚糖的3种生物组装技术——定向组装、酶促组装、自组装的制备原理和过程, 评述了基于壳聚糖的BioMEMS在生物、医学、环境领域中的应用现状, 并展望了今后的研究方向。

Abstract:

Chitosan is a polymer with good biocompatibility, unique pH-responsive solubility, convenient modification and easier film-formability. Chitosan could serve as an active mediator between biological components and microfabricated devices to prepare biological micro electro mechanical systems (BioMEMS) with high selectivity and sensitivity. Recently, there has been a growing interest in BioMEMS based on biofabrication of chitosan. We reviewed the mechanisms and processes of three biofabrication methods based on chitosan, including directed assembly, enzymatic assembly and self-assembly. Current applications and research progress in biological, medical and environmental fields are also discussed. Finally, future research directions are prospected.