酿酒酵母纤维素乙醇统合加工 (CBP) 的策略及研究进展

Progress and strategies on bioethanol production from lignocellulose by consolidated bioprocessing (CBP) using Saccharomyces cerevisiae

摘要:

木质纤维素乙醇的统合生物加工过程 (Consolidated bioprocessing，CBP) 是将纤维素酶和半纤维素酶生产、纤维素水解和乙醇发酵过程组合或部分组合，通过一种微生物完成。统合生物加工过程有利于降低生物转化过程的成本，越来越受到研究者的普遍关注。酿酒酵母Saccharomyces cerevisiae是传统的乙醇发酵菌株。介绍了影响外源基因在酿酒酵母中表达水平的因素，纤维素酶和半纤维素酶在酿酒酵母中表达研究进展及利用酿酒酵母统合加工纤维素乙醇的策略。

Abstract:

Ethanol production from lignocelluloses of consolidated bioprocessing (CBP) is a system in which cellulase and hemicellulase production, substrate hydrolysis, and fermentation are combined or partially combined by ethanologen microorganisms that express cellulolytic or hemicellulolytic enzymes or engineering cellulolytic microorganisms with ethanol production properties. Due to its potential for significant cost reduction, CBP is receiving more and more attention. In this review article, we discuss the factors that influence the expression level of cellulases in Saccharomyces cerevisiae and updated progress in bioethanol production from lignocellulose by the CBP strategy using the yeast species.