应用新城疫病毒治疗肿瘤的研究进展

Progress in using Newcastle disease virus for tumor therapy: a review

摘要:

新城疫病毒可以特异地杀伤肿瘤细胞，而对正常细胞没有伤害，目前在临床实验中认为是安全、有效的溶瘤试剂。随着近年来反向遗传操作技术的日趋成熟，该技术开始应用到新城疫病毒溶瘤效果的优化方面，通过改造新城疫病毒的F基因，及表达重组粒细胞巨噬细胞集落刺激因子，干扰素-γ，白细胞介素-2和肿瘤坏死因子-α等肿瘤杀伤因子，使该病毒具备更加优越的肿瘤杀伤能力，成为肿瘤治疗领域一个新兴的亮点，为癌症的临床治疗提供了崭新的前景。以下将简要介绍应用反向遗传操作技术重组新城疫病毒优化肿瘤治疗效果的研究进展，以及本实验室在相关领域的研究情况。

Abstract:

Naturally existing Newcastle disease virus (NDV) can specifically execute oncolytic ability in clinical studies. Reports from clinical trials using NDV as oncolytic agents showed promise and warrant results in cancer therapy. In recent years, reverse genetics technology has been used widely in the studies of NDV virology. More recently, the technology was applied to optimize the oncolytic efficacy of NDV, for instance, modification of the F gene, and expression of GM-CSF, IFN-γ, IL-2 or TNF-α. NDV is widely investigated in cancer therapy and will definitely offer a prosperous future for clinical cancer therapeutics. We reviewed the developments of cancer therapy by recombinant NDV using reverse genetics technology, as well as our own experience in this domain.