微生物法生产1,3-二羟基丙酮代谢工程研究进展

Progress in metabolic engineering of microbial production of 1,3-dihydroxyacetone

摘要:

1,3-二羟基丙酮是一种重要的化工原料和医药中间体，广泛应用于化妆品、医药、食品等领域。以下综述了微生物法生产1,3-二羟基丙酮的代谢途径和关键酶，以及微生物法生产1,3-二羟基丙酮所涉及的代谢工程技术的研究进展。指出利用基因工程的方法对菌株进行改造，提高甘油脱氢酶催化活性，同时根据菌株的代谢特性，对发酵过程进行调控，提高1,3-二羟基丙酮的得率，是今后的研究方向。

Abstract:

1,3-Dihydroxyacetone is widely used in cosmetics, medicines and food products. We reviewed the recent progress in metabolic pathways, key enzymes, as well as metabolic engineering for microbial production of 1,3-dihydroxyacetone. We addressed the research trend to increase yield of 1,3-dihydroxyacetone by improving the activity of glycerol dehydrogenase with genetic engineering, and regulating of fermentation process based on metabolic characteristic of the strain.