微生物发酵产二十二碳六烯酸代谢机理的研究进展

Progress in metabolic mechanism of docosahexenoic acid production by fermentation

摘要:

二十二碳六烯酸 (简称DHA) 是一种重要的长链多不饱和脂肪酸，对人体具有重要的生理功能。微生物发酵生产的DHA与鱼油来源的DHA相比，具有诸多优点，其发展前景广阔。以下从发酵菌株、代谢途径、关键酶以及油脂积累机制等方面进行了综述，为通过代谢工程等技术手段进一步提高DHA产量提供了参考。

Abstract:

Docosahexenoic acid (DHA) is an important polyunsaturated fatty acid which is beneficial to human health. Compared with the DHA derived from fish oil, DHA by microbial production possesses many advantages, and has a bright prospect. In this article, we reviewed strains, metabolic pathway, key enzymes and mechanism of lipid accumulation for microbial production of DHA. Those information would be greatly helpful for further improving DHA production by metabolic engineering.