丙酮丁醇梭菌的遗传操作系统

Genetic modification systems for Clostridium acetobutylicum

摘要:

丙酮丁醇梭菌是极具潜力的替代燃料——生物丁醇的合成菌，受到各国研究者的普遍关注。丙酮丁醇梭菌菌株改造是生物丁醇产业化进程中的一项重要工作，其中遗传操作是核心内容之一。以下对丙酮丁醇梭菌的遗传操作系统的发展历史、种类和原理进行了综述，分析了目前几种遗传操作系统的局限性，并对其发展进行了展望。

Abstract:

Clostridium acetobutylicum, a biofuel-butanol producer, has attracted worldwide interests. Strain improvement is important for the process of biobutanol industrialization where efficient genetic modification systems are essential. In this review, the history of genetic modification systems of C. acetobutylicum was introduced, and the types and principles of these systems and their disadvantages are summarized and analysed. The development of updated genetic modification systems for C. acetobutylicum is also proposed.