生产聚羟基脂肪酸酯的微生物细胞工厂

Microbial cell factories for production of polyhydroxyalkanoates

摘要:

聚羟基脂肪酸酯 (PHA) 是一类由微生物合成的、生物可再生、生物可降解、具有多种材料学性能的高分子聚合物，在很多领域有着广泛的应用前景。以下从辅酶工程、代谢工程、微氧生产等方面综述了微生物法生产PHA的研究进展，并对利用PHA合成基因提高基因工程菌的代谢潜能进行了讨论。

Abstract:

Polyhydroxyalkanoates (PHA) are diverse polyesters synthesized by a variety of bacteria as intracellular carbon and energy storage compounds. As bio-renewable and biodegradable materials with diverse properties, PHA have drawn industrial attentions for their potential applications in many fields. This review focuses on recent strain developments for PHA production via cofactor engineering and metabolic engineering. The microaerobic production of PHA and application of PHA synthesis genes for improving robustness of industrial microorganisms are addressed.