家畜胚胎干细胞多能性候选信号通路及分子标志

Pluripotency candidate signaling network and transcription factors in domesticated ungulates: a review

摘要:

家畜胚胎干细胞具有重要的生物学意义和广阔的应用前景。以下对比了小鼠、人胚胎干细胞多能性调控信号通路的异同，阐述了小鼠、人胚胎干细胞与家畜胚胎干细胞在多能性分子标志上的差异，并结合本实验室开展绵羊胚胎干细胞研究的实际经验，对目前家畜胚胎干细胞建系中可能存在的多能性候选信号通路及分子标志进行了探讨。

Abstract:

Domesticated ungulates embryonic stem (ES) cells have great significances in biology and wide application prospects. This review compared the key signaling pathways related with pluripotency between mouse and human ES cells, and the difference of transcription factors in mouse, human and domesticated ungulates ES cells were elaborated. Finally the pluripotency candidate signaling network and transcription factors related in the derivation of domesticated ungulates ES cell were discussed combined with practical experience of ovine embryonic stem cell derivation in our laboratory.