漆酶空间结构、反应机理及应用

Structure, catalytic mechanism and applications of laccases: a review

摘要:

漆酶 (EC 1.10.3.2) 属于多铜氧化酶家族，可以催化氧化酚类和芳香类化合物，利用自由基反应机理完成4 个电子的转移，并将分子氧还原成水。漆酶具有非常保守的拓扑学结构，结合作者自身工作实践，对漆酶结构与功能的最新研究进展进行综述，其中对漆酶的三维结构、活性中心、催化机理研究和最新的应用进展作重点阐述。

Abstract:

Laccases (benzenediol: oxygen oxidoreductases; EC 1.10.3.2) are copper-containing polyphenol oxidases that can oxidize a wide range of aromatic compounds, concomitantly with the transfer of four electrons and the reduction of molecular oxygen to water. The progress on the research of laccases structure and function is reviewed. Their three-dimensional structures and catalytic mechanism, as well as their applications in different fields are emphasized.