鱼类干扰素反应及分子调控

Fish interferon response and its molecular regulation: a review

摘要:

干扰素反应在脊椎动物抵抗病毒感染过程中发挥重要作用。近年来，鱼类干扰素抗病毒免疫反应的研究取得了重要进展，不仅克隆鉴定了一系列鱼类干扰素系统基因，而且通过功能研究揭示了鱼类具有类似于高等哺乳类的干扰素反应。但是，鱼类干扰素反应及分子调控具有自身特点。以下综述了最近这方面的研究结果。

Abstract:

Interferon response is the first line of host defense against virus infection. Recent years have witnessed tremendous progress in understanding of fish innate response to virus infection, especially in fish interferon antiviral response. A line of fish genes involved in interferon antiviral response have been identified and functional studies further reveal that fish possess an IFN antiviral system similar to mammals. However, fish virus-induced interferon genes contain introns similar to mammalian type III interferon genes although they encode proteins similar to type I interferons, which makes it hard to understand the evolution of vertebrate interferon genes directly resulting in a debate on nomenclature of fish interferon genes. Actually, fish display some unique mechanisms underlying interferon antiviral response. This review documents the recent progress on fish interferon response and its molecular mechanism.