重症手足口病免疫球蛋白治疗的机理探讨

Mechanism of intravenous immunoglobulin therapy for severe hand-foot-mouth disease: a review

摘要:

手足口病是由多种肠道病毒感染导致的一种急性儿科传染病。近年来，我国肠道病毒71型 (EV71) 手足口病发病率急剧上升，重症病例时有报道，严重威胁儿童健康。临床上对于重症手足口病的治疗缺乏有效手段，主要以对症治疗和支持疗法为主。静脉注射人免疫球蛋白由健康献血员血浆提取纯化而来，含有包括EV71在内的多种肠道病毒的中和抗体，可作为重症手足口病被动免疫和免疫调节的重要手段，值得关注。

Abstract:

Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by various enteroviruses. Recently, large HFMD outbreaks caused by enterovirus type 71 (EV71) have been frequently reported in China, posing great threats on children’s health. There is no specific antiviral therapy for severe HFMD, and patient management mainly depends on supportive and symptomatic treatment. Intravenous immunoglobulin (IVIG) is a pharmaceutical preparation of human IgG that is pooled from thousands of healthy blood donors, and contained neutralization antibodies against various enteroviruses, including EV71. IVIG therapy should be carefully administrated for severe HFMD considering its role on passive immunization against EV71 and immune regulation.