先进生物燃料导向的脂肪酸途径合成生物学改造

Advanced biofuel-oriented engineering of fatty acid pathway：a review

摘要:

化石能源日益枯竭，迫切需要寻找新型燃料。脂肪族生物燃料由于其热值高、性能好而受到广泛重视。微生物脂肪酸代谢途径是生产先进生物燃料的重要途径。文中综述了近几年基于合成生物学理念改造脂肪酸途径的进展，介绍了合成生物学在微生物柴油、中长链脂肪醇、长链烃类化合物生物合成中的应用，并展望了脂肪族生物燃料的发展方向。

Abstract:

Biofuel is in high demand as an alternative energy source for petroleum and diesel. Fatty acid-based biofuel has higher energy density and better compatibility with existing infrastructures. Microbial fatty acid biosynthetic pathway is important to develop biofuel. In this article, recent progresses on the modification and reconstruction of fatty acid metabolism for the production of biofuel were reviewed, with a focus on micro-diesel, long chain fatty alcohol and alkane. Problems, solutions and directions for further development of fatty acid-based biofuel were also discussed in the respect of synthetic biology.