抗菌肽融合表达研究进展

Research progress in fusion expression of antimicrobial peptides

摘要:

抗菌肽抗菌谱广、活性稳定，且具有与抗生素不同的抗菌机制，在抑杀病原微生物的同时不易产生耐药性，因而在食品、饲料、医药等领域具有重要的应用价值。基因工程技术是降低抗菌肽生产成本的主要方式，其中融合表达在提高抗菌肽产量方面起到了重要作用。文中综述了抗菌肽融合表达的国内外研究进展，探讨了部分融合标签用于抗菌肽表达的策略，并对今后的发展提出了自己的看法。

Abstract:

Antimicrobial peptides (AMPs) are of great significance in the field of food, feed and medicine due to their wide spectrum of antimicrobial activity and new mechanism of action different from conventional antibiotics. AMPs production from natural sources is usually limited, and chemical synthesis is not economically practical, especially for the production of long peptides. Therefore, heterologous expression of AMPs has been widely studied as an alternative, and fusion expression plays an important role in increasing production. The present review mainly focuses on the types and bioactivities of AMPs. In addition, the recent strategies to the most commonly used carrier proteins for fusion expression of AMPs and prospects for future research were also discussed.