非典型应答调控蛋白活性调控机制

Progress in the understanding of the function of atypical response regulators: a review

摘要:

双组分信号转导系统是生物中广泛存在的调控系统，通常由组氨酸激酶和应答调控蛋白 (Response regulator，RR) 两个组分构成。典型的RR通过一个磷酸化机制调控活性。非典型应答调控蛋白在细菌中广泛存在，并调控细菌的生长发育、抗生素合成、Fe的转运等多种生理功能。以下主要综述目前研究比较清楚的非典型应答调控蛋白的结构和功能方面的进展，并以链霉菌中杰多霉素生物合成途径中的非典型应答调控蛋白JadR1为例，阐明调控蛋白活性调控的新机制。

Abstract:

Two component system is a signal transduction system. It typically consists of a sensor histitine kinase and a cognate response regulator (RR) component. The activity of RR is regulated by a phosphorylation dependent mechanism. In recent years, the existence of atypical response regulators (ARRs), which rely on a phosphorylation independent mechanism to regulate their activity, have been recognized. ARRs are involved in the regulation of bacterial growth and development, antibiotic biosynthesis, iron transport, among others. Here we review the recent advances in the understanding of the structure and function of atypical response regulators, by using JadR1, a regulator in jadomycin biosynthesis in Streptomyces, as an example to elucidate the novel mechanism used by ARR to fine-tune its activity.