稀有人参皂苷IH901在体内外的生物转化及其生物活性

Biotransformation in vivo/vitro and bioactive properties of rare ginsenoside IH901

摘要:

人参皂苷IH901是近年人参代谢组学研究中新发现的一种稀有人参皂苷。IH901在天然人参中并不存在，系口服人参后通过系列肠道微生物在体内代谢转化，最终入血的主要代谢产物之一。最新药理学研究表明，IH901在抗肿瘤、抗炎、抗糖尿病和抗衰老等方面均表现出良好的生物活性，是人参在体内发挥活性作用的主要物质。近年来，在体内转化IH901的理论指导下，国内外学者通过体外酶转化和微生物转化等生物工程技术在大规模提取制备IH901等研究方面均取得突破性的进展。以下综述了稀有人参皂苷IH901在体内外的生物转化及其生物活性等研究进展。

Abstract:

Recent metabolomics research revealed a new ginseng ginsenoside IH901 that is synthesized by intestinal microbial transformation in oral administration of ginseng. IH901 shows various biological activities, including anti-tumor, anti-inflammatory, anti-diabetic, and anti-aging. In recent years, great effort has been made to prepare IH901 by microbial and enzymatic transformation in a large scale. In this paper, we reviewed the biotransformation pathways both in vivo and in vitro and bioactive properties of rare ginsenoside IH901.