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生物法合成戊二胺研究进展
作者:
基金项目:

国家自然科学基金(No. 21176910), 天津市科技支撑计划 (No. 11ZCKFSY00900), 天津市应用基础及前沿技术研究计划(No. 11JCYBJC 09600), 长江学者与创新团队项目(No. IRT1166) 资助。


Progress in biosythesis of diaminopentane
Author:
  • Dongxia Li

    Dongxia Li

    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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  • Ming Li

    Ming Li

    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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  • Hongxin Wang

    Hongxin Wang

    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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  • Shuya Wang

    Shuya Wang

    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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  • Fuping Lu

    Fuping Lu

    Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, National Engineering Laboratory for Industrial Enzymes, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
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Fund Project:

National Natural Science Foundation of China (No. 21176190), Key Technology Research and Development Program of Tianjin, China (No. 11ZCKFSY00900), Tianjin Research Program of Application Foundation and Advanced Technology (No. 11JCYBJC09600), Changjiang Scholars and Innovative Research Team (No. IRT1166).

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    摘要:

    随着经济快速发展，大气污染和全球变暖的趋势日益恶化。世界上每年消耗大量石化资源来源的聚酰胺，戊二胺作为聚酰胺的重要组成单体，生物法合成戊二胺具有经济学和生态学双重意义。目前, 生物法合成戊二胺的工程菌主要有谷氨酸棒状杆菌和大肠杆菌，文中从微生物中戊二胺的代谢、戊二胺合成途径的关键酶和转运蛋白、戊二胺生产最佳代谢途径和戊二胺产量的预测、代谢工程研究进展等方面综述了生物法合成戊二胺的最新研究现状和进展，并对其前景进行了展望。

    Abstract:

    Air pollution and global warming are increasingly deteriorating. Large amounts of polyamides derived from fossil fuel sources are consumed around the world. Cadaverine is an important building monomer block of bio-based polyamides, thus biotechnological processes for these polymers possess enormous ecological and economical potential. Currently, the engineered strains for biological production of cadaverine are Corynebacterium glutamicum and Escherichia coli. We review here the latest research progress of biosynthesis of cadaverine including metabolism of cadaverine in microorganisms, key enzymes and transport proteins in cadaverine synthesis pathway, optimum pathways and cadaverine yields.

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引用本文

李东霞,黎明,王洪鑫,王舒雅,路福平. 生物法合成戊二胺研究进展[J]. 生物工程学报, 2014, 30(2): 161-174

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历史
  • 收稿日期:2013-05-18
  • 在线发布日期: 2014-02-10
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