氨基糖苷抗生素庆大霉素： 基础研究的新进展及应用研究的新潜力

Aminoglycoside gentamicin research: fundamental progress and new application prospects

摘要:

庆大霉素是临床上重要的氨基糖苷类抗生素。近年来，伴随现代生物技术水平的发展，人们对该抗生素有了更深入的了解。本文综述了近年来国内外关于庆大霉素的作用机制和耐药机制、生物合成途径和结构改造，及其新活性等方面研究成果，并对庆大霉素的应用与发展前景进行展望。

Abstract:

As an important aminoglycosides antibiotic, gentamicin has been used clinically over decades. With the development in modern biological technology, the mechanisms of gentamicin action and resistance, its biosynthesis and structural modification were studied in great depth. Meanwhile, its emerging novel bioactivities and potential applications are also under extensive exploration. Here we summarize the latest progresses and prospects towards the future development of gentamicin for more efficient and effective uses.