血管生成素样蛋白家族表达调控及其在动物分子育种领域的现状分析

Expression of angiopoietin-like proteins for animal breeding: a review

摘要:

血管生成素样蛋白 (Angiopoietin-like proteins, Angptls) 是与脂类、葡萄糖、能量代谢和血管生成密切相关的蛋白质家族，现已发现8个成员，因其在代谢调控和动物辅助选育方面发挥有重要作用而备受研究人员的关注。以下综述了该蛋白家族的结构、介导的信号通路、上游调控基因及代谢网络等方面，并结合课题组研究工作对其应用于动物育种领域的现状和问题进行了分析，对前景作了展望。

Abstract:

Angiopoietin-like proteins are a family of proteins that are closely related to lipid, glucose and energy metabolism, as well as angiogenesis. To date, eight Angptls have been discovered, namely Angptl1 to Angptl8 that play key roles in metabolic regulation and marker assisted selection. In this review, we summarized current progress on the structure, signaling pathways, upstream regulatory genes and metabolic network of Angptl1-8. Finally, in combination with our work, the status and problems of animal breeding as well as the future prospects for Angptls were discussed.