IL28B基因在乙型肝炎病毒感染中的作用

Function of the IL28B gene in Hepatitis B virus infection

摘要:

乙型肝炎病毒 (Hepatitis B virus，HBV) 感染是引发乙型肝炎的病因，慢性化程度较高，后期可诱发肝硬化甚至肝癌。IL28B基因属于新型干扰素λ家族，已有研究报道其遗传多态性与HBV感染者的治疗效果和病毒自然清除率具有相关性。通过探讨IL28B 基因遗传易感性与HBV感染、患者治疗应答和病毒清除的关系，可以进一步了解宿主基因多态性在HBV感染治疗和病毒自然清除中的作用机制，为乙肝患者个体化医疗提供一定的理论基础。

Abstract:

Hepatitis B virus (HBV) that causes Hepatitis B with a high chronic rate, could lead to hepatic cirrhosis and hepatocellular carcinoma. The IL28B gene belongs to a new interferon family λ and its genetic polymorphisms are identified to be associated with treatment effect and viral clearance. The purpose of this review is to discuss the role of the IL28B gene in treatment response and viral clearance of HBV-infected individuals, and further to reveal the mechanisms. This review could provide a theoretical basis for personalized medicines of HBV patients.