生物大分子自组装合成多维纳米生物结构与器件

Synthesis of multi-dimensional nano biostructures and biodevices through self-assembly of biomacromolecules

摘要:

生物体通过指导的自组装合成种类繁多、功能特异的天然纳米结构，它们在生命过程中扮演重要角色。按照自组装体的维度，可以分为线状 (一维)、层状 (二维)、笼状 (三维) 生物纳米结构。通过设计，这些生物大分子纳米结构可在细胞“工厂”中重组制备，且可通过合成生物学技术对其组装和功能化进行理性设计和调控，成为功能性纳米器件。这类纳米生物结构和器件已经在生物传感、催化、肿瘤热疗、药物递送、组织工程、生物电池等领域获得展示或应用。相关研究正在成为合成生物学和纳米生物学的一个交叉领域，受到关注。

Abstract:

There are various nanostructures in biological system. They are made of biological molecules via self-assembly with well-organized architectures and specific functions. These nanostructures can be grouped into lines, layers and cages, corresponding to one-, two- and three-dimensional structures, respectively. The bionanostructures can serve as the models or templates for biosynthesis of biodevices with desired functions by rational design. Proof-of-concept studies have shown their attractive performance in practical applications, e.g., biosensors, catalysis, tumor thermo-therapy, drug delivery, tissue engineering, and batteries.