生物合成聚3-羟基丙酸酯的研究进展

A systematic review of biosynthesis of poly (3- hydroxypropionate)

摘要:

聚3-羟基丙酸酯 (P3HP) 作为聚羟基脂肪酸酯家族 (PHAs) 中的新型热塑性塑料，具有生物降解性和生物相容性等优点。目前，未见野生微生物可以合成P3HP的报道，生产途径主要为化学法和生物法。其中，通过化学法或添加3-HP单体及其结构类似物作为前体的P3HP合成效率低、成本高且不具环保性；而通过构建和改造工程菌的生物代谢途径，能够利用廉价、可再生的碳源，已经逐渐成为研究热点。本文综述了国内外P3HP生物合成研究进展，并对甘油途径、丙二酸单酰辅酶A (Malonyl-CoA) 途径和β-丙氨酸途径等合成方法进行了优缺点分析，为生物合成P3HP的深入研究奠定理论基础。

Abstract:

Poly (3-hydroxypropionate) (P3HP), a new member of thermoplastic of family polyhydroxyalkanoates (PHAs), has excellent characteristics of biodegradability and biocompatibility. By now no reports can be found about wild-type bacteria that naturally synthesize P3HP, so the main way to produce P3HP is chemical and biological methods. Chemical method by adding high cost 3-HP monomers or their structural analogs as precursors, has the drawbacks of toxicity, low effectiveness and high cost. Biological method using engineered strain may utilize inexpensive and renewable carbon source to produce P3HP and has gradually become more and more popular. We systematically review here the biosynthesis of P3HP research progress. The advantages and disadvantages of biosynthesis pathways of glycerol pathway, malonyl-CoA pathway and β-alanine pathway were analyzed.