达托霉素耐药分子机制研究进展

Molecular mechanisms underlying daptomycin resistance

摘要:

环脂肽抗生素达托霉素抗菌活性强，致病菌不容易产生耐药性，已成为治疗革兰氏阳性菌特别是耐药菌感染的一线药物。但由于广泛使用，仍然出现了达托霉素耐药菌。细胞膜磷脂代谢和细胞壁结构动态与致病菌达托霉素耐药密切相关。文中综述了达托霉素作用机制和耐药机制，以期对药物研发和临床用药有所裨益。

Abstract:

Due to potent bactericidal activity and low rate of drug-resistance, daptomycin is recognized as first line antibiotic to treat serious infections caused by drug-resistant Gram-positive pathogens. However, the incidence of daptomycin resistance is increasing due to its widespread application. Alteration of cell wall homeostasis and membrane phospholipid metabolism is involved in daptomycin resistance. The unique mode of action underlying daptomycin resistance in important pathogens, including Staphylococcus aureus and Enterococci, is presented in this paper.