定制酶分子机器/细胞工厂，引领生物制造产业未来

Customization of enzyme molecular machine and cell factory, leading the future of biomanufacturing industry

摘要:

工业酶制剂研发与应用已经渗透到各大工业领域，但中国作为用酶大国、产酶小国面临重大挑战，鉴于以化学催化为核心的基础物质加工业面临资源、能源和环境三大危机，酶工程与生物催化已被列入许多国家的科技与产业发展战略，应用高效、清洁的生物催化技术是实现化学工业可持续发展以及发酵工业产业升级的重要途径之一。文中以2017年第十一届中国酶工程学术研讨会杜邦-杰能科中国酶工程杰出贡献奖获得者特邀报告为基础整理编写而成，从自主酶库构建、酶分子机器/细胞工厂创制及产业化应用等角度概述当前酶工程与生物催化发展现状及前景。

Abstract:

The development and application of industrial enzymes have penetrated major industrial fields. China faces a major challenge as a large country in applying enzyme but a small one in producing enzyme. Biocatalysis has become an important technology and strategy of industrial development in the world since chemical catalysis encounters the crises from resource, energy and environment. The application of efficient and clean biocatalysis is one of the important ways to realize the sustainable development of chemical industry and to modernize the fermentation industry. From perspective of the industry-university-research cooperation, we reviewed the current status and the future development of enzyme engineering from the aspects of enzyme resources, customization of enzyme molecular machine and cell factory.