细菌耐药性应对策略研究进展

Progress in strategies to combat antimicrobial resistance

摘要:

细菌耐药性 (Antimicrobial resistance，AMR) 持续增长，但新上市抗生素数量却持续下降。抗生素耐药基因 (Antimicrobial resistance gene，ARG) 和抗生素耐药菌感染已严重威胁人类健康。因此，需要多方面联合采取措施来应对AMR所带来的各种挑战，包括创新生物医药、改善抗生素使用和抗生素耐药监测系统、减少抗生素耐药基因产生速度、阻止健康护理相关感染和多重抗生素耐药菌传播与扩散、开发微生物学快速诊断方法与设备、减少临床和兽医抗生素滥用等。庆幸的是，AMR已受到各国政要、科学家和企业家等的高度重视与支持，相信随着新技术、新产品的不断问世和管理新措施的不断出台，AMR问题一定会得到控制和缓解。

Abstract:

Antimicrobial resistance is on the rise while the number of antibiotics being brought to market continues to drop. Drug-resistant genes and drug-resistant bacteria infection have seriously threatened human health. Therefore, antimicrobial resistance presents an ongoing challenge that requires multifaceted approaches including: biomedical innovation; improved surveillance of antibiotic consumption and antimicrobial resistance generated rates; prevention of health-care-associated infections and transmission of multidrug-resistant bacteria and environmental dissemination; rapid microbiological diagnosis; and curtailed clinical and veterinary misuse. Fortunately, combating antimicrobial resistance has been highly valued and supported by the government, scientists and entrepreneurs of various countries. With the continuous introduction of new technologies, new products, and new management measures, the problem of antimicrobial resistance must be controlled and alleviated.