非洲猪瘟防控及疫苗研发：挑战与对策

Prevention, control and vaccine development of African swine fever: challenges and countermeasures

摘要:

非洲猪瘟是由非洲猪瘟病毒引起的一种接触传染性、广泛出血性猪烈性传染病，最急性和急性感染死亡率高达100%。自2018年8月我国发生首起非洲猪瘟疫情后，3个多月内，已有18个省份累计暴发69起，给我国养猪业造成了沉重打击。从目前非洲猪瘟全球流行态势及世界各国防控经验来看，我国非洲猪瘟防控和根除面临的形势不容乐观，亟需安全有效的疫苗用于该病的防控。文中结合当前非洲猪瘟病原学最新研究成果，系统总结了非洲猪瘟防控策略、疫苗研究进展及其面临的挑战，重点分析了疫苗研发历程、存在的问题、未来发展方向以及商业化应用所面临的关键科学问题，以期为我国非洲猪瘟防控及病原和疫苗研究提供借鉴。

Abstract:

African swine fever (ASF) is a hemorrhagic and devastating infectious disease of pigs caused by African swine fever virus (ASFV), with mortality up to 100%. The first ASF outbreak occurred in China in August 2018, followed by 69 cases of ASF in 18 provinces in more than three months, causing a heavy burden to the pig industry. Based on the global epidemic situation of ASF and the experience of prevention and control in other countries, the ASF control and eradication situation in China is extremely complex and serious. The availability of effective and safe ASF vaccines is an urgent requirement to reinforce control and eradication strategies. Therefore, this article starts with the latest findings of ASFV, summarizes the progress in prevention and control strategies and vaccine approaches for ASFV. We also discuss the challenges of preventing and controlling ASF, focusing on current vaccine strategies, the gaps, future research directions, and key scientific issues in commercial applications. We hope to provide basic information for the development of vaccines and prevention control strategies against this disease in China.