谷氨酸脱氢酶与几种肿瘤的关系

Correlation of glutamate dehydrogenase with several tumors

摘要:

大多数生物体中都含有谷氨酸脱氢酶(Glutamate dehydrogenase, GDH) (E.C. 1.4.1.2–1.4.1.4)。在真核生物中，该酶主要存在于线粒体中，并在氮和碳的代谢以及信号通路中起着至关重要的作用。研究发现谷氨酸脱氢酶与肿瘤发生及发展有一定的关系，对于肿瘤研究具有一定意义，但是关于其与人类肿瘤的关系方面的综述很少见。文中对谷氨酸脱氢酶与乳腺癌、胶质瘤、结直肠癌以及卵巢癌等的关系进行了归纳和总结，希望可以为相关研究提供帮助。

Abstract:

Most organisms contain glutamate dehydrogenase (E.C. 1.4.1.2–1.4.1.4). In eukaryotes, the enzyme is mainly present in mitochondria. This enzyme plays a vital role in the metabolism of nitrogen and carbon and the signaling pathway. Studies have found that glutamate dehydrogenase has a certain relationship with the occurrence and development of tumors, which is significant for tumor research, but reviews on its relationship with human tumors are rare. This review summarized the relationship between glutamate dehydrogenase and breast cancer, glioma, colorectal cancer and ovarian cancer, etc, thus providing assistance for related research.