微流控芯片在中枢神经系统疾病中的应用与展望

Application and prospect of microfluidic chip in central nervous system diseases

摘要:

近年来，随着微流体技术和生物微电子机械系统技术的不断发展，人类中枢神经系统 (CNS) 的微流体平台及相关疾病的体外模型逐渐得到了广泛的研究。微流体平台可以更好地模拟体内环境，同时能够控制结构、微环境和外来刺激。文中总结了微流控芯片在CNS的基本技术和CNS疾病中的应用。此外，文中对微流控芯片在CNS中的研究进行了展望，强调了通过跨学科的共同努力能够实现更高程度的仿生学挑战。

Abstract:

In recent years, many human central nervous systems (CNS) of microfluidic platforms and related disease models in vitro have been built with the continuous development of the microfluidic technology and biological microelectronics mechanical systems technology. Microplatforms have emerged to provide a better approximation of the in vivo scenario with better control of the structure, microenvironment and stimuli. This review summarized the basic technology of microfluidic chips in CNS and the application in CNS diseases. In addition, the research of microfluidic chip in CNS diseases has been also prospected. We also highlight challenges that can be addressed with interdisciplinary efforts to achieve more biomimicry.