双特异性抗体在抗病毒方面的研究进展

Advances in research of bispecific antibodies for antivirus therapy

摘要:

随着基因工程抗体的快速发展，双特异性抗体技术也日趋成熟。双特异性抗体能够同时结合两个以上不同的抗原表位，在免疫治疗中具有独特的优势。双特异性抗体已经广泛应用于癌症治疗如黑色素瘤、霍奇金淋巴瘤以及肝癌、胃癌等，以及炎症方面的治疗如类风湿性关节炎、牛皮癣与克罗恩病等。双特异性抗体在病毒免疫治疗方面则刚刚起步。文中对双特异性抗体用于病毒免疫治疗的研究进展进行了综述，特别是在体内外效果较好的产品，为用于病毒免疫治疗的双特异性抗体药物开发与研究提供一定的参考。

Abstract:

With the rapid development of antibody genetic engineering, bispecific antibody technology has been advanced. They are capable of binding two or more different epitopes simultaneously, thus offering specific advantages over natural monoclonal antibodies in immunotherapy. Bispecific antibodies have been successfully used in cancer therapy (e.g. melanoma, Hodgkin’s lymphoma, liver cancer, and stomach cancer)?and?inflammation therapy (e.g. rheumatoid arthritis, psoriasis and Crohn’s disease), but are still in their early stage for viral immunotherapy. In this study, we reviewed the research progress of bispecific antibodies for immunotherapy of virus infections, especially those with good effects in vivo and in vitro, to provide references for the research and development of bispecific antibodies for antivirus treatment.