改造肠道微生物在疾病诊断与治疗中的应用

Applications of engineered intestinal bacteria in disease diagnosis and treatment

摘要:

肠道微生物是近年来新兴的热门研究领域，它与人类疾病健康存在着密切的关系。伴随高通量测序技术的发展，研究者们发现了肠道微生物在疾病的诊断与治疗中的潜力。合成生物学通过设计编辑工具以及反馈回路，可以构建具有诊断疾病或者靶向治疗疾病的肠道微生物工程菌株。这些工程菌能够对环境进行感知、计算和反馈。本文概述了改造后的肠道微生物在疾病诊断与治疗中的应用，同时阐述了目前改造后肠道微生物的临床应用现状，并对“工具短缺”以及目前改造后肠道微生物所存在的安全性等问题进行了讨论。

Abstract:

Intestinal bacteria interact closely with human health and diseases. With the development of high-throughput sequencing technologies, researchers have discovered the potential of intestinal bacteria in the diagnosis and treatment of diseases. Meanwhile, synthetic biology strategies are applied to engineer these bacteria for clinical applications. These engineered intestinal microbial are constructed by designing editing tools and feedback loops to gain functions of diagnose or targeted therapy. Consequently, these engineered bacteria are capable of sensing, calculating and responding to the environment. In this review, we summarize the recent advances in engineered intestinal bacteria in disease diagnosis and treatment. Furthermore, we also discuss the current status and future prospect of the engineered intestinal bacteria regarding their clinical applications, market, and safety issues.