组蛋白赖氨酸特异性去甲基化酶1A在肿瘤发生发展中的作用

Function of histone demethylasehistone lysine-specific demethylase 1A in tumor initiation and progression

摘要:

组蛋白赖氨酸特异性去甲基化酶1A (Histone lysine-specific demethylase 1A，KDM1A) 作为组蛋白赖氨酸特异性去甲基化酶 (Histone lysine-specific demethylase) 家族的一员，在信号传导、染色体重构、胚胎发育、造血和糖脂代谢等生物学过程中起着重要的作用。近年来的研究及临床证据表明，KDM1A的表达与肿瘤的发生发展密不可分，通过与不同的复合物结合并介导不同的下游信号通路，对多种肿瘤的生长增殖起着关键的调节作用，例如前列腺癌、乳腺癌、肺癌和肝癌等。在大多数情况下，KDM1A在肿瘤的发生发展中扮演着促癌基因角色。文中结合近年来有关文献，阐述了KDM1A在多种肿瘤发生及发展中的研究进展，总结了其作用机制，并对以KDM1A为靶点的抑癌治疗的应用前景进行了展望。

Abstract:

As a member of the histone lysine-specific demethylase family, KDM1A plays a pivotal role in biological processes including signal transduction, chromatin reprogramming, embryo development, hematopoiesis, glucose and lipid metabolism. Recently, increasing studies and clinical evidences suggest that the expression of KDM1A is related to initiation and development of tumors and plays a key role in regulating of initiation and development of tumors, such as prostate cancer, breast cancer, lung cancer and liver cancer. KDM1A binds to distinct complexes and mediates different downstream signaling pathways. However, KDM1A often plays an oncogenic role in the initiation and development of tumors. Based on the current literatures, we describe the latest research of KDM1A in the initiation and progression of various tumors, and summarize its mechanism of actions, to provide clues for cancer therapy.