新早期胃癌标志物PRDX4通过清除ROS促进胃癌的发生发展

New early gastric cancer marker PRDX4 promote the tumorigenesis and progression of gastric cancer via eliminating ROS

摘要:

胃癌是全球第四大最常见的癌症，也是全球癌症中引起死亡的第二大原因。为了降低胃癌的死亡率，目前亟需解决的问题是发现新的早期胃癌特异性的标志物，提高早期胃癌的检出率，从而从根本上解决胃癌死亡率高的问题。实验室前期研究发现过氧化物酶4 (Peroxiredoxin 4，PRDX4) 具有早期胃癌标志物的潜能，文中通过建立恶性转化模型及转化细胞过表达等方法，研究PRDX4在转化细胞中的作用。结果显示PRDX4通过减少转化细胞中活性氧 (Reactive oxygen species，ROS) 含量，使细胞处在利于生长增殖的微环境中，从而促进细胞发生恶性转化，即PRDX4通过清除ROS促进胃癌的发生发展。

Abstract:

Gastric cancer is the fourth most common cancer in the world and the second leading cause of death in cancer worldwide. In order to reduce the mortality rate of gastric cancer, the problem that needs to be solved at present is to find new specific markers of early gastric cancer and increase the detection rate of early gastric cancer, thus fundamentally solving the problem of high mortality of gastric cancer. Previous studies in our laboratory found that Peroxiredoxin 4 (PRDX4) has the potential for early gastric cancer markers. In this study, the role of PRDX4 in transformed cells was studied by establishing a malignant transformation model and transforming cell overexpression, the experiment proves that PRDX4 is responsible for growth and proliferation by reducing the content of reactive oxygen species (ROS) in transformed cells. In the microenvironment, it promotes the malignant transformation of cells, that is, PRDX4 promotes the development of gastric cancer via eliminating ROS.