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生物工程学报
国家自然科学基金 (No. 31600848)，重庆市科委自然科学基金 (No. CSTC2015JCYJA10031)，重庆高校创新团队建设计划 (No. CXTDX201601032)，重庆科技学院科研基金 (No. CK2016Z02)，重庆科技学院研究生科技创新项目 (No. YKJCX1820208) 资助。
- Qiao Hu
Qiao Hu
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Yuxin Shi
Yuxin Shi
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Xiaoling Yang
Xiaoling Yang
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Jing Zhang
Jing Zhang
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Bo Li
Bo Li
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Xiaoling Liao
Xiaoling Liao
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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在本站中查找 - Xue Liu
Xue Liu
1 Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331, China;2 Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, China
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National Natural Science Foundation of China (No. 31600848), Chongqing Municipal Natural Science Foundation (No. CSTC2015JCYJA10031), Chongqing University Innovation Team Construction Plan (No. CXTDX201601032), Chongqing University of Science and Technology Research Fund (No. CK2016Z02), Chongqing University of Science and Technology Graduate Science and Technology Innovation Project (No. YKJCX1820208).
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神经递质是神经系统中至关重要的组成部分，神经递质释放的时间和空间变化是神经网络中信息处理的核心，可视化监测神经递质的生物传感器是探究各类生理和病理活动的重要工具。文中综述了近年来具有较高时间和空间分辨率的监测神经递质时空分布变化技术的研究进展，介绍了对谷氨酸、多巴胺、γ-氨基丁酸和乙酰胆碱这4类重要的神经递质的检测方法，并归纳总结了各类检测方法的基本原理和优缺点，为设计具有高时空分辨率的神经递质传感器提供一个较为系统的参考。
Neurotransmitters play an important role in nervous system. Temporal and spatial changes of neurotransmitter distribution are crucial to information processing in neural networks. Biosensors that can visually monitor neurotransmitters are one of the vital tools to explore a variety of physiological and pathological activities. This article reviews recent advances in monitoring neurotransmitters with high temporal and spatial resolution, and introduces the latest fluorescent imaging methods for typical neurotransmitters, including glutamate, dopamine, γ-aminobutyric acid and acetylcholine. The article also summarizes the basic principles, advantages and disadvantages of various visually detection methods, and provides systematic suggestions for designing neurotransmitter sensors with high temporal and spatial resolution.
引用本文
胡巧,史雨馨,杨晓玲,张静,李波,廖晓玲,刘雪. 神经递质的可视化荧光检测技术研究进展[J]. 生物工程学报, 2020, 36(6): 1051-1059
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- 收稿日期:2019-09-27
- 在线发布日期: 2020-06-24
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